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What is Ativan?

Ativan is a psychotropic compound that belongs to the group of benzodiazepine tranquilizers. It is widely used in narcological, psychiatric, neurological and general medical practice. If medical recommendations are violated, it can provoke addiction and cause the development of pharmacy addiction.

Lorazepam is a potent medicine that is used in psychiatric practice to treat neuroses, depression, panic and other disorders.

The remedy has a long-lasting effect on the body, helping patients cope with negative experiences or somatoform manifestations.

Composition

Depending on the form of release, the drug contains the active substance — lorazepam (0,5; 1; 2; 2,5, 4; 8 mg.) and auxiliary components:

• in tablet forms — it is talc, gelatin, titanium dioxide, magnesium stearate, lactose, etc.;
• in injection — distilled water.

In its pure form, lorazepam is a powder that is difficult to dissolve in liquids and has a white or slightly yellowish color.

Effect on the human body

Anxiolytics from the benzodiazepine group quickly overcome the blood-brain barrier and reach the central nervous system. The active substance increases the sensitivity of GABA receptors to gamma-aminobutyric acid. The corresponding channels open, chlorine ions quickly enter the cells, causing hyperpolarization of cell membranes.

As a result, the excitability of brain neurons decreases, so their activity slows down. The main effect of Ativan on the body:

• reducing anxiety;
• elimination of stress, anxiety, fear, emotional arousal;
• improving sleep quality;
• getting rid of spasms;
• normalization of the autonomic nervous system;
• prevention of vomiting.

Ativan is prescribed in short courses as monotherapy or in combination with other medications, including to facilitate the initial period of antidepressant therapy for anxiety and depressive disorders.

Application in medical practice

The drug has a fairly wide range of applications due to its sedative, hypnotic, muscle relaxant and anticonvulsant properties. It is effective for combating various mental disorders, insomnia, withdrawal syndrome and other pathological conditions.

In anesthesiology, Lorazepam is used to prepare a patient for operations, painful diagnostic and therapeutic procedures. The dosage is prescribed by a doctor taking into account the nature of the pathology. The duration of therapy is also determined by the specialist.

Taking the medication for a long time (more than a month) or in high doses is addictive. Therefore, treatment with such means should always take place under the strict supervision of doctors.

Narcotic effect

A person may feel dependent on the use of the drug after using it for four or more weeks. This is especially true for those individuals who consciously increase the dosage and use the medicine more often than was prescribed in the instructions. In such cases, psychological and physical drug addiction occurs, which is very difficult to cope with.

At first, the patient feels considerable relief after taking a tranquilizer. However, after the end of the course of drug therapy, pathological conditions appear again. The dependent begins to take the drug voluntarily. Due to the development of tolerance, the effect of "Ativan" becomes less pronounced, the previous amount does not provide the desired effect.

In an effort to get relief, the patient increases the dose. As a result, an overdose occurs, which manifests itself in the form of:

• drowsiness, fatigue;
• depression;
• headaches and dizziness;
• memory problems;
• sleep disorders or lack thereof;
• failures of the gastrointestinal tract;
• allergic reactions, etc.

So addiction entails a number of problems on the part of the psyche and body.

In some cases, drug addicts use Ativan as a recreational drug for abstinence or in the absence of the ability to get the usual psychotropic substances. Alcoholics also sometimes resort to a similar method of relieving the condition. The result in both cases is poly-drug addiction. The only sure way out of such a situation is to contact an experienced narcologist.

Signs of drug abuse

A person taking an anxiolytic becomes addicted. He wants to use the medicine not for the purpose of treatment, but to get a relaxing effect. "Ativan" in large quantities has a strong narcotic effect on the body. The individual loses the instinct of self-preservation, does not feel the danger of what is happening. Reality at this moment, as a rule, is perceived in a distorted form.

Dosage

According to the instructions for use, Lorazepam therapy should be started with the lowest effective dose, the course should not be long. Substances of this type with a large dosage and a long course can cause dependence in the patient. With the abrupt withdrawal of Ativan, it is highly likely that the patient may have a withdrawal or rebound syndrome, so you need to stop the course gradually reducing the dose of the drug.

Depending on the severity of the patient's condition, the drug should be taken 1 mg 2-3 times a day. To get the effect of a sleeping pill, it is enough to drink 1 mg of Ativan half an hour before bedtime. For the treatment of psychiatric diseases, a dose of 3.0-7.5 mg of the substance is prescribed, divided into 3-4 doses per day. To prepare the patient for surgery, a dose of 1-2 mg is used immediately before the operation or for several hours before the intended intervention.

Minors and women during pregnancy or lactation are strictly prohibited from using the drug in any doses.

Drug addiction?

Special instructions for use

During the period of taking the anxiolytic, it is forbidden to drink alcohol of any kind, even in minimal quantities. The instructions do not apply to patients with hypotension, cerebral vascular sclerosis, body weight deficiency or chronic heart failure. For them, the dosages are selected individually, and the therapeutic volumes of the drug are regularly corrected. Exceeding the recommended doses, alcohol consumption, prolonged therapy creates a risk of developing drug dependence.

Contraindications

In addition to early childhood, lactation and pregnancy, the instructions for the medication "Ftivan (Lorazepam)" leads to several more contraindications. The list includes intolerance to the main component of the drug, hypersensitivity to benzodiazepine derivatives. Comatose or shock state, pathological muscle weakness, angle-closure glaucoma are also bans. Persons in a state of alcoholic intoxication or acute drug intoxication should refrain from therapy.

Separately, experts distinguish relative contraindications to the use of the product, in which therapy is possible in exceptional cases due to high risks.

These are considered to be reduced liver and/or kidney performance, organic lesions of the central nervous system, loss of control over the performance of arbitrary movements. If you have a history of any kind of addiction, in old age, against the background of psychosis or severe depression, taking medication can do more harm than good. With increased caution, the product is prescribed to persons with sleep apnea syndrome, protein deficiency in blood plasma.

In the presence of addiction, depression, in old age, taking medication is not recommended.

Drug interaction

Ativan may react with some other drugs. When taken simultaneously with Probenecid, there is an acceleration of the onset of action of lorazepam, as well as an increase in its duration of action. In this regard, with the simultaneous use of these drugs, the dose of lorazepam should be reduced.

If Lorazepam and Clozapine are taken simultaneously, the patient has the following symptoms:

• sedation;
• hypersalivation;
• hypotension;
• delirium;
• ataxia;
• respiratory disorders.

Theophylline and Aminophylline during interaction with drugs of the beznodiazepine group may cause a decrease in the sedative effect of this drug. If Sodium valproate is used together with Ativan, the drug increases the concentration in the blood, and at the same time the rate of its excretion from the body decreases.